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KMID : 0376219950310010049
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Chonnam Medical Journal
1995 Volume.31 No. 1 p.49 ~ p.56
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Prediction of CO2 retention with peak inspiratory flow in chronic obstructive pulmonary disease
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Yang Ju-Yeoul
Lim Sang-Chul
Park Hyeong-Kwan
Seo Jae-Sung
Na Hyun-Joo
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Abstract
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Background and Method: Despite significant but similar degree of expiratory air-flow limitation, wide ranges of PaCO2 can be seen in chronic obstructive pulmonary disease(COPD), and it is questionable whether analysis of only expiratory parameters on pulmonary
function
test (PFT)is enough to estimate the severity of COPD and can predict the CO2 retention. To evaluate the usefulness of inspirtory parameters of PFT to predict CO2 retention, The author conducted pulmonary function test(FVC maneuver) and arterial
blood
gas analysis concurrently in 32 patients with COPD suffering from severe degree of expiratory airflow limitation (FFV1≤50% of predicted value).
@ES Result :
@EN Between CO2 retainers (PaCO2) 42 mmHg, N=16) and Non-retainers (PaCO2≤42mmHg, N=16), there were no significant differences in their age, sex distribution, FVC, FEV1, FIVC and PaO2. Peak inspiratory flow(PIF) was significantly lower in CO2
retainers
than in non-retainers (49.5±2.4 vs. 88.8±25.4% of predicted value, P<0.001), and FEV1/FVC (45.1±6.1 vs. 54.7±10.7, P<0.01) also. PIF (r=-0.5431, P<0.01), FEV1/FVC (R=-.3346, p<0.05). FEV1 (r=-.2983, P<0.05) showed significant inverse
correlation
with PaCO2. Among the above parameters, PIF was the only independent parameters that could determine PaCO2 by the stepwise multiple regression analysis. A prediction equation of PaCO2 on this base shows that PaCO2 =-0.16756PIF+55.061162.
@ES Conclusion:
@EN It was suggested that PIF reflecting the airflow airflow limitation during the inspiratory phase had an important contribution to the CO2 retention as well as some expiratory such as FEV1, FEV1/FVC.
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KEYWORD
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